Hotels in South Main, Memphis from CA $123

South Main is quite unique, but for a similar feel and quality, consider staying in the Medical District or Downtown.

The Medical District, located just north of South Main, offers a modern and convenient experience. It's home to several prominent medical institutions and has seen significant development in recent years. You'll find a good selection of contemporary hotels with high-end fitness equipment and dining options, often suiting those visiting the hospitals or attending conferences. This area is particularly well-suited for business travellers due to its proximity to the medical facilities and easy access to major roads.

Downtown Memphis, directly west of the Medical District and accessible via Main Street, provides a more traditional city experience with a focus on entertainment and dining. This area boasts iconic landmarks like Beale Street, the FedEx Forum, and the Orpheum Theatre. It's a great choice for those who want to be in the thick of the city's nightlife and have a wide array of restaurants and entertainment venues within walking distance.

For exceptional stays in South Main, travellers highly recommend ARRIVE Memphis, Big Cypress Lodge, The Westin Memphis Beale Street, The Central Station Memphis, Curio Collection by Hilton, and Hyatt Centric Beale Street Memphis.

The 4-star ARRIVE Memphis, with an outstanding 9.6 rating, is celebrated for its friendly and amazing staff, beautiful and clean rooms, and superb location. Guests also praise the excellent bar and delicious breakfast. The hotel features designer toiletries, Egyptian cotton sheets, and premium bedding for a truly comfortable stay, and is a Beaux Arts property with secured valet parking. It is also conveniently located near the W.C. Handy Memphis Home and Museum and The Peabody Memphis.

The 5-star Big Cypress Lodge, rated 9.0, offers an array of luxurious amenities including private indoor hot tubs, secured valet parking, and bathrobes. Guests consistently highlight the comfortable and beautiful rooms, exceptional service from the amazing staff, and the big bathtubs. The hotel also boasts a shopping mall on-site and resort views, with a fireplace in some rooms. It is located just 0.6 km from St. Mary's Catholic Church and 1.7 km from the W.C. Handy Memphis Home and Museum.

The 4-star The Westin Memphis Beale Street, with an 8.8 rating, is appreciated for its helpful and great staff, clean and quiet rooms, and excellent location. The on-site restaurant and valet service also receive high praise. Amenities include 24-hour room service, bathrobes, designer toiletries, and premium bedding. The hotel is very close to the W.C. Handy Memphis Home and Museum and The Peabody Memphis.

The 4-star The Central Station Memphis, Curio Collection by Hilton, rated 9.0, is known for its clean and quiet rooms, friendly and amazing staff, and excellent location. Travellers often mention the super comfy beds and beautiful artwork. The hotel offers premium bedding, Egyptian cotton sheets, couples dining, evening entertainment, and champagne service. It is within easy reach of the W.C. Handy Memphis Home and Museum and The Peabody Memphis.

The 4-star Hyatt Centric Beale Street Memphis, with an 8.8 rating, is popular for its friendly and helpful staff, superb location, and clean rooms. Guests also enjoy the great breakfast. The hotel features a river view, an outdoor pool with sun loungers, bathrobes, and secured covered valet parking. It is located very close to the W.C. Handy Memphis Home and Museum and The Peabody Memphis.

For excellent family hotels in South Main, consider the Residence Inn by Marriott Memphis Downtown or the Comfort Inn Memphis Downtown.

The 3-star Residence Inn by Marriott Memphis Downtown, with an impressive 9.2 rating, is highly recommended for families. Guests appreciate the complimentary breakfast, which includes a buffet option, and the free grocery shopping service, making it very convenient for longer stays. The hotel also provides free cribs and sofa beds, ensuring comfort for all family members. It is conveniently located near St. Mary's Catholic Church and The Peabody Memphis.

Another great option is the Comfort Inn Memphis Downtown, rated 8.8. This hotel offers practical amenities for families such as connecting rooms, child-friendly window designs, and playpens, alongside free cribs and sofa beds. Guests frequently praise the clean rooms, friendly staff, and the excellent breakfast provided. It's also well-situated, being close to St. Mary's Catholic Church and W.C. Handy Memphis Home and Museum.

The Hampton Inn & Suites Memphis-Beale Street, with an 8.6 rating, is another fantastic choice for families. It provides free full breakfast and has a pool for family enjoyment. Cribs, connecting rooms, and sofa beds are available to accommodate different family needs. Its location is a highlight, being very close to W.C. Handy Memphis Home and Museum and The Peabody Memphis.

For a 3.5-star option, the Crowne Plaza Memphis Downtown Hotel by IHG, rated 7.8, offers a good range of family-friendly amenities including a pool, free cribs, and child-friendly window designs. Families will also appreciate the connecting rooms, kids' meals, and free area shuttle. It is very close to St. Mary's Catholic Church.

Finally, the 4-star Sheraton Memphis Downtown Hotel, rated 7.6, provides amenities like free cribs, sofa beds, connecting rooms, and kids' meals. The hotel also offers free WiFi and allows pets to stay free, which can be a great bonus for families travelling with their furry friends. It is conveniently located near St. Mary's Catholic Church.

For a luxurious 5-star hotel experience in South Main, the Big Cypress Lodge is an excellent choice.

This remarkable 5-star hotel boasts an impressive 9.0 rating and offers a range of exceptional amenities. Guests frequently praise the comfortable and beautiful rooms, the friendly and amazing staff, and the exceptional service. Each room features a private indoor hot tub, bathrobes, and a fireplace, creating a truly opulent stay. The hotel is conveniently located within a shopping mall and provides secure valet parking. Nearby points of interest include St. Mary's Catholic Church, just 0.6 km away, and The Peabody Memphis, 1.4 km from the hotel.

For a highly-rated spa hotel in South Main, consider the MOXY Memphis Downtown.

This 3-star hotel, with an 8.4 rating, offers a relaxing experience with its treatment rooms and designer toiletries, great for unwinding after a day of exploring. Guests frequently highlight the clean rooms and the nice, great staff, as well as the friendly bar staff. The hotel also features accessible fitness facilities and a fitness centre, and its Beaux-Arts property design adds a touch of elegance. It is conveniently located near points of interest such as The Peabody Memphis, just 0.5 km away, and the Orpheum Theatre, 0.7 km away.

For hotels in South Main offering complimentary breakfast, consider the La Quinta Inn & Suites by Wyndham Memphis Downtown, Residence Inn by Marriott Memphis Downtown, Comfort Inn Memphis Downtown, Hampton Inn & Suites Memphis-Beale Street, and Springhill Suites By Marriott Memphis Downtown.

The 3-star La Quinta Inn & Suites by Wyndham Memphis Downtown, with an impressive 9.2 rating, provides a free breakfast, including a convenient to-go option. Guests appreciate the clean rooms, friendly staff, and easy access to downtown. The hotel also offers free parking and free WiFi. It's located just 0.4 km from the W.C. Handy Memphis Home and Museum.

The 3-star Residence Inn by Marriott Memphis Downtown, also rated 9.2, offers a free buffet breakfast and complimentary grocery shopping service. Guests frequently comment on the helpful staff, good-sized, comfortable rooms, and tasty breakfast. The hotel is well-located, being only 0.2 km from The Cotton Museum at the Memphis Cotton Exchange.

Comfort Inn Memphis Downtown, rated 8.8, provides a free buffet breakfast. Travellers highlight the clean rooms, friendly staff, and convenient location close to downtown. Free WiFi is also available, and parking is noted as easy. It is situated 0.6 km from The Cotton Museum at the Memphis Cotton Exchange.

Hampton Inn & Suites Memphis-Beale Street, with an 8.6 rating, includes a free full breakfast and offers suites. Guests consistently praise the friendly staff, superb location, and nice, clean rooms. The breakfast is described as above average, and the beds are comfortable. It's very close to the W.C. Handy Memphis Home and Museum, just 0.2 km away.

The 3-star Springhill Suites By Marriott Memphis Downtown, rated 8.4, offers a free full breakfast. Guests frequently mention the comfortable, big rooms and the excellent staff. The breakfast is often described as fantastic. This hotel is located 0.4 km from The Cotton Museum at the Memphis Cotton Exchange.

For top pet-friendly hotels in South Main, consider ARRIVE Memphis, The Westin Memphis Beale Street, La Quinta Inn & Suites by Wyndham Memphis Downtown, Crowne Plaza Memphis Downtown Hotel by IHG, and Sheraton Memphis Downtown Hotel.

The 4-star ARRIVE Memphis, with an exceptional 9.6 rating, is an excellent choice for dog owners, offering food and water bowls for your canine companion. Guests consistently praise its amazing and friendly staff, as well as its beautiful and clean rooms. The hotel's location is considered perfect, and the on-site bar receives high marks. It is conveniently located just 1.0 km from the W.C. Handy Memphis Home and Museum and 0.8 km from Beale Street Landing.

Another highly-rated option is The 4-star Westin Memphis Beale Street, which has an 8.8 rating. This hotel also welcomes dogs and provides food and water bowls. Guests frequently mention the helpful staff, clean and quiet rooms, and the great location. The hotel's restaurant is often described as excellent. It is situated 0.3 km from the W.C. Handy Memphis Home and Museum and 0.4 km from The Peabody Memphis.

The 3-star La Quinta Inn & Suites by Wyndham Memphis Downtown, with a 9.2 rating, is a great choice for both dogs and cats. Travellers appreciate the nice and clean rooms, the friendly and helpful staff, and the great breakfast. The free and easy parking is also a significant benefit, and its location is considered great and close to downtown. It is 0.4 km from the W.C. Handy Memphis Home and Museum and 0.5 km from The Peabody Memphis.

The 3.5-star Crowne Plaza Memphis Downtown Hotel by IHG, rated 7.8, is another pet-friendly option that welcomes both dogs and cats, providing food and water bowls and a dog exercise area. Guests have highlighted the excellent and helpful staff, comfy beds, and amazing breakfast. The facilities are considered good, and the location is described as great. It is 0.1 km from St. Mary's Catholic Church and 1.4 km from the W.C. Handy Memphis Home and Museum.

Finally, the 4-star Sheraton Memphis Downtown Hotel, rated 7.6, is a good choice for those travelling with dogs, offering free pet stays. The hotel also provides free WiFi, complimentary cribs, and free toiletries. Guests often mention the helpful and great staff, comfortable and clean rooms, and its great location. It is 0.2 km from St. Mary's Catholic Church and 1.4 km from the W.C. Handy Memphis Home and Museum.

For top boutique hotels in South Main, consider ARRIVE Memphis, The Central Station Memphis, Curio Collection by Hilton, Hu. Hotel, and MOXY Memphis Downtown.

The 4-star ARRIVE Memphis, with an outstanding 9.6 rating, offers a Beaux-Arts property design and provides amenities such as designer toiletries, Egyptian cotton sheets, and premium bedding. Guests frequently mention the friendly and amazing staff, the beautiful and clean rooms, and the superb location. It is conveniently located near the Orpheum Theatre and FedExForum, both within a kilometre.

Another excellent option is The Central Station Memphis, Curio Collection by Hilton, a 4-star hotel rated 9.0. This hotel also features a Beaux-Arts property design and offers accessible parking options. Guests appreciate the clean and quiet rooms, the friendly staff, and the super comfy beds. It is located just over a kilometre from The Peabody Memphis.

The 3.5-star Hu. Hotel, with an 8.4 rating, offers an Art Deco property design. Its amenities include premium bedding, deep soaking bathtubs, and free designer toiletries. Guests often highlight the friendly and helpful staff, the nice and clean rooms, and the great location. It is very close to The Peabody Memphis, just 0.4 km away.

Finally, MOXY Memphis Downtown, rated 8.4, features a Beaux-Arts property design and offers designer toiletries and fitness facilities. Visitors frequently praise the clean and great rooms, as well as the nice and great staff. This hotel is also conveniently located near The Peabody Memphis, just 0.5 km away.

For excellent budget hotels in South Main, consider the Residence Inn by Marriott Memphis Downtown, La Quinta Inn & Suites by Wyndham Memphis Downtown, Comfort Inn Memphis Downtown, Hampton Inn & Suites Memphis-Beale Street, and Springhill Suites By Marriott Memphis Downtown.

The 3-star Residence Inn by Marriott Memphis Downtown, with an impressive 9.2 rating, offers complimentary breakfast, including a buffet, and free WiFi. Guests appreciate the helpful staff, comfortable and good-sized rooms, and the tasty breakfast. It is conveniently located near St. Mary's Catholic Church and The Cotton Museum at the Memphis Cotton Exchange.

Another highly-rated option is the 3-star La Quinta Inn & Suites by Wyndham Memphis Downtown, also with a 9.2 rating. This hotel provides free self-parking, a complimentary to-go breakfast, and free WiFi. Guests often remark on the nice, clean rooms, friendly and helpful staff, and its great location close to downtown.

The Comfort Inn Memphis Downtown, with an 8.8 rating, provides a free buffet breakfast and complimentary WiFi. Guests praise the clean rooms, friendly staff, and its great location. It's close to St. Mary's Catholic Church and The Cotton Museum at the Memphis Cotton Exchange.

The Hampton Inn & Suites Memphis-Beale Street, rated 8.6, offers a free full breakfast and complimentary WiFi. Travellers frequently highlight the friendly and helpful staff, great location, and nice, clean rooms. It is very close to the W.C. Handy Memphis Home and Museum.

Finally, the 3-star Springhill Suites By Marriott Memphis Downtown, with an 8.4 rating, includes a free full breakfast and complimentary WiFi. Guests often mention the comfortable and spacious rooms, wonderful staff, and excellent breakfast. It is situated close to St. Mary's Catholic Church and The Cotton Museum at the Memphis Cotton Exchange.

For a romantic stay in South Main, couples might consider the Big Cypress Lodge or The Central Station Memphis, Curio Collection by Hilton.

The 5-star Big Cypress Lodge, with an excellent 9.0 rating, offers a truly great experience. Many rooms feature private indoor hot tubs and fireplaces, great for intimate evenings. Guests frequently praise the comfortable and beautiful rooms, exceptional service, and friendly staff. The hotel is also conveniently located near attractions like The Peabody Memphis and the Orpheum Theatre.

Another wonderful option is the 4-star The Central Station Memphis, Curio Collection by Hilton, also rated 9.0. This hotel is known for its couples' dining options and its quiet, clean rooms with super comfy beds. Guests appreciate the excellent location, with The Peabody Memphis and the Orpheum Theatre within easy reach.

The best time to visit South Main is during the spring (March to May) and autumn (September to November) when the weather is mild and pleasant.

During these seasons, you'll find comfortable temperatures great for exploring the neighbourhood's art galleries, boutiques, and historic sites on foot. The mild weather also makes it ideal for enjoying outdoor dining at the many restaurants along South Main Street without the intense heat and humidity of summer.

Spring and autumn are excellent for couples looking for a relaxed trip. You can stroll hand-in-hand to attractions like the National Civil Rights Museum or catch a trolley ride down to Beale Street in the evening. The crisp air in autumn, especially, adds a lovely touch to walks around the historic district.

For solo travellers, these seasons offer a great opportunity to connect with the city's culture at a comfortable pace. You can easily navigate the area, pop into local shops, and enjoy the public art installations without feeling rushed or overheated.

Many Expedia hotel reservations are refundable, provided that you cancel before the hotel’s cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right South Main hotel for you.

Hotel prices in South Main often vary, but you can find a great deal from CA $123 on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.